Online Supplementary Information to Scharinger et al. Leoligin, the Major Lignan from Edelweiss, Inhibits 3-hydroxy-3-methyl-glutaryl-CoA Reductase and Reduces Cholesterol Levels in ApoE -/- mice Short title: Leoligin – a new cholesterol-lowering drug
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Leoligin, the Major Lignan from Edelweiss, Inhibits 3-hydroxy-3-methyl-glutaryl-CoA Reductase and Reduces Cholesterol Levels in ApoE -/mice Short title: Leoligin – a new cholesterol-lowering drug Bernhard Scharinger, Barbara Messner, Adrian Türkcan, Daniela Schuster, Anna Vuorinen, Florian Pitterl, Katharina Heinz, Kathrin Arnhard, Günther Laufer, Michael Grimm, Hermann Stuppner, Herbert Oberacher, Philipp Eller, Andreas Ritsch, and David Bernhard
منابع مشابه
Leoligin, the Major Lignan from Edelweiss (Leontopodium nivale subsp. alpinum), Promotes Cholesterol Efflux from THP-1 Macrophages
Leoligin is a natural lignan found in Edelweiss (Leontopodium nivale ssp. alpinum). The aim of this study was to examine its influence on cholesterol efflux and to address the underlying mechanism of action. Leoligin increases apo A1- as well as 1% human plasma-mediated cholesterol efflux in THP-1 macrophages without affecting cell viability as determined by resazurin conversion. Western blot a...
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